Semaglutide
ozempicwegovyrybelsus
Long-acting GLP-1 agonist (Ozempic / Wegovy). Now also available as an oral 25 mg tablet approved for weight management (launched Jan 2026) — see the Oral Semaglutide entry.
- Half-life
- 6.9 d
- Out of system
- ~5 weeks
- Route
- Subcutaneous
- Level
- Intermediate
Long-acting — weekly dosing keeps levels steady. After the last dose, roughly 97% has cleared in ~5 weeks (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Semaglutide is used for
- Sustained weight loss — typically 10–15% body weight over 12+ months
- Strong appetite + craving suppression
- Improved A1c and fasting glucose for type-2 diabetes
How it's typically used
Prescription titration: 0.25 → 0.5 → 1 → 2.4 mg weekly (Wegovy) over ~16 weeks. Follow your prescriber.
What to watch for
- GI side effects (nausea, constipation) hit ~30% of users early in titration
- Pancreatitis warning — stop and call a doctor for persistent abdominal pain
- Avoid with personal/family history of medullary thyroid carcinoma or MEN-2
About GLP-1 & weight loss
- What they are
- Incretin analogues — GLP-1 and dual/triple agonists. They slow stomach emptying and act on appetite centres in the brain, so you eat less without white-knuckling it.
- How they're run
- One subcutaneous shot a week for most, on the same day each week. Doses climb in steps every four weeks; that slow titration is what keeps side effects tolerable.
- What to watch
- Nausea, constipation, and reflux are near-universal in the first month. Muscle is lost alongside fat unless you keep protein high and keep lifting. Tell any surgeon or anaesthetist you are on one.
Full guide
Tracking Semaglutide: Dose Titration and Side Effects
A pragmatic guide to logging a semaglutide titration. What to capture daily, weekly, and at every dose increase.
Other glp-1 & weight loss
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.