Cagrilintide
cagrisema
Long-acting amylin analog. Now discussed mainly as half of CagriSema (with semaglutide) — REDEFINE data ~22.7% loss, filing expected late 2026.
- Half-life
- 6.6 d
- Out of system
- ~5 weeks
- Route
- Subcutaneous
- Level
- Intermediate
Long-acting — weekly dosing keeps levels steady. After the last dose, roughly 97% has cleared in ~5 weeks (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Cagrilintide is used for
- Long-acting amylin analog — appetite + satiety
- Studied with semaglutide (CagriSema) for added weight loss
How it's typically used
Trial range: titrated toward 2.4 mg subcutaneous weekly.
What to watch for
- Nausea and GI effects, especially when combined with a GLP-1
- Still investigational; long-term safety unknown
- Source legitimately; grey-market risk
About GLP-1 & weight loss
- What they are
- Incretin analogues — GLP-1 and dual/triple agonists. They slow stomach emptying and act on appetite centres in the brain, so you eat less without white-knuckling it.
- How they're run
- One subcutaneous shot a week for most, on the same day each week. Doses climb in steps every four weeks; that slow titration is what keeps side effects tolerable.
- What to watch
- Nausea, constipation, and reflux are near-universal in the first month. Muscle is lost alongside fat unless you keep protein high and keep lifting. Tell any surgeon or anaesthetist you are on one.
Full guide
Cagrilintide: A Tracking Guide for a Long-Acting Amylin Analog
What cagrilintide is, why it is being studied with semaglutide as CagriSema, and how to track appetite, weight, and tolerability.
Other glp-1 & weight loss
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.