Dulaglutide
trulicity
Weekly GLP-1 agonist (Trulicity). Clean titration ladder; tradeoff assessment vs newer compounds.
- Half-life
- 3.8 d
- Out of system
- ~3 weeks
- Route
- Subcutaneous
- Level
- Intermediate
Levels carry over between doses — every 2–3 days is typical. After the last dose, roughly 97% has cleared in ~3 weeks (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Dulaglutide is used for
- Weekly GLP-1 agonist (Trulicity) with a clean titration
- Modest weight loss and strong glucose control
How it's typically used
Prescription titration: 0.75 → 1.5 → up to 4.5 mg weekly.
What to watch for
- GI side effects (nausea, constipation) early in titration
- Pancreatitis warning; stop for persistent abdominal pain
- Avoid with medullary thyroid carcinoma or MEN-2 history
About GLP-1 & weight loss
- What they are
- Incretin analogues — GLP-1 and dual/triple agonists. They slow stomach emptying and act on appetite centres in the brain, so you eat less without white-knuckling it.
- How they're run
- One subcutaneous shot a week for most, on the same day each week. Doses climb in steps every four weeks; that slow titration is what keeps side effects tolerable.
- What to watch
- Nausea, constipation, and reflux are near-universal in the first month. Muscle is lost alongside fat unless you keep protein high and keep lifting. Tell any surgeon or anaesthetist you are on one.
Full guide
Dulaglutide (Trulicity): A Practical Tracking Guide
Weekly GLP-1 receptor agonist with a clean titration shape — what to track and how it compares to semaglutide and tirzepatide.
Other glp-1 & weight loss
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.