Tirzepatide
mounjarozepbound
Dual GLP-1 / GIP agonist (Mounjaro / Zepbound). In Dec 2024 Zepbound also became the first drug FDA-approved for obstructive sleep apnea in adults with obesity.
- Half-life
- 5.0 d
- Out of system
- ~4 weeks
- Route
- Subcutaneous
- Level
- Intermediate
Long-acting — weekly dosing keeps levels steady. After the last dose, roughly 97% has cleared in ~4 weeks (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Tirzepatide is used for
- Strongest weight loss in mainstream trials — ~20% over 72 weeks
- Dual GLP-1 / GIP agonism vs semaglutide's GLP-1 only
- Excellent glucose control
How it's typically used
Prescription titration: 2.5 → 5 → 10 → 15 mg weekly (Zepbound) over ~20 weeks.
What to watch for
- Worse GI side effects than semaglutide for some users
- Gallbladder + pancreatitis warnings — same class risks
- Avoid with medullary thyroid history or MEN-2
About GLP-1 & weight loss
- What they are
- Incretin analogues — GLP-1 and dual/triple agonists. They slow stomach emptying and act on appetite centres in the brain, so you eat less without white-knuckling it.
- How they're run
- One subcutaneous shot a week for most, on the same day each week. Doses climb in steps every four weeks; that slow titration is what keeps side effects tolerable.
- What to watch
- Nausea, constipation, and reflux are near-universal in the first month. Muscle is lost alongside fat unless you keep protein high and keep lifting. Tell any surgeon or anaesthetist you are on one.
Full guide
Tirzepatide: A Tracking Guide for the Dual GLP-1 / GIP Titration
A focused guide to tracking a tirzepatide protocol — the titration, the unique GIP-side effects, sulfur burps, and what to log week-over-week.
Other glp-1 & weight loss
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.