Exenatide
byetta bydureon
Original GLP-1 (Byetta / Bydureon) — Gila monster venom-derived. Twice-daily or weekly formulations.
- Half-life
- 2.4 h
- Out of system
- ~12 h
- Route
- Subcutaneous
- Level
- Intermediate
Short-acting — protocols usually dose daily. After the last dose, roughly 97% has cleared in ~12 h (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Exenatide is used for
- First-in-class GLP-1 (Byetta/Bydureon)
- Appetite and glucose control with a long track record
How it's typically used
Prescription: 5–10 mcg twice daily (Byetta) or 2 mg weekly (Bydureon).
What to watch for
- Twice-daily form is inconvenient; GI side effects common
- Pancreatitis warning; injection-site nodules with the weekly form
- Avoid with thyroid carcinoma history
Common questions
- What is the half-life of Exenatide?
- Exenatide has an approximate elimination half-life of 2.4 h. Short-acting — protocols usually dose daily.
- How long does Exenatide stay in your system?
- Roughly 97% of a dose has cleared after five half-lives — about ~12 h for Exenatide. That is the window that matters for washouts, bloodwork and surgery.
- How is Exenatide taken?
- Exenatide is typically administered by the subcutaneous route. Prescription: 5–10 mcg twice daily (Byetta) or 2 mg weekly (Bydureon).
- What are the risks of Exenatide?
- Twice-daily form is inconvenient; GI side effects common Pancreatitis warning; injection-site nodules with the weekly form Avoid with thyroid carcinoma history
About GLP-1 & weight loss
- What they are
- Incretin analogues — GLP-1 and dual/triple agonists. They slow stomach emptying and act on appetite centres in the brain, so you eat less without white-knuckling it.
- How they're run
- One subcutaneous shot a week for most, on the same day each week. Doses climb in steps every four weeks; that slow titration is what keeps side effects tolerable.
- What to watch
- Nausea, constipation, and reflux are near-universal in the first month. Muscle is lost alongside fat unless you keep protein high and keep lifting. Tell any surgeon or anaesthetist you are on one.
Full guide
Exenatide (Byetta and Bydureon): Tracking the Original GLP-1
The first-in-class GLP-1 receptor agonist, derived from Gila monster venom — twice-daily and weekly versions tracked.
Other glp-1 & weight loss
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.