Urolithin A
A gut-derived metabolite, sold as Mitopure, that promotes mitophagy — the recycling of damaged mitochondria. Human trials report gains in muscle endurance.
- Half-life
- 1.0 d
- Out of system
- ~5 days
- Route
- Oral
- Level
- Intermediate
Daily dosing holds steady levels. After the last dose, roughly 97% has cleared in ~5 days (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Urolithin A is used for
- Stimulates mitophagy, the recycling of worn-out mitochondria
- Human trials report improved muscle endurance and strength
- A naturally occurring metabolite with a favorable tolerability profile
How it's typically used
Clinical trials describe roughly 500 mg daily, framed as the studied range and not a recommendation.
What to watch for
- Benefits build gradually over weeks rather than immediately
- Not everyone produces it naturally, so response may vary
- Long-term effects are still being studied
- Sold as a dietary supplement, not evaluated by the FDA to treat any disease
About Longevity
- What they are
- Compounds studied for cellular ageing — mitochondrial function, senescent-cell clearance, telomere and autophagy pathways.
- How they're run
- Mixed routes: some injected in short annual or biannual courses, others taken orally every day.
- What to watch
- Endpoints here are measured in decades, so nobody has human outcome data. Bloodwork and function markers are the only feedback you will get in a realistic timeframe.
Full guide
Urolithin A: A Tracking Guide for a Mitophagy Activator
An evidence-aware look at urolithin A, a gut-derived metabolite with human muscle and endurance data, sold as a well-tolerated supplement.
Other longevity
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.