Spermidine
A naturally occurring polyamine, available as a supplement, that induces autophagy — the cell's self-cleaning process. It is being studied for its links to healthy aging.
- Half-life
- Not established
- Out of system
- —
- Route
- Oral
- Level
- Intermediate
What Spermidine is used for
- Induces autophagy, the cell's self-cleaning process
- Associated in observational studies with healthy aging and longevity
- Found naturally in foods and generally well tolerated
How it's typically used
Supplement and dietary studies describe roughly 1 mg or more daily, framed as the studied range and not a recommendation.
What to watch for
- Human evidence is largely observational rather than from large trials
- Optimal dose and long-term effects are not well defined
- Effects are subtle and accrue over long periods
- Sold as a dietary supplement, not evaluated by the FDA to treat any disease
About Longevity
- What they are
- Compounds studied for cellular ageing — mitochondrial function, senescent-cell clearance, telomere and autophagy pathways.
- How they're run
- Mixed routes: some injected in short annual or biannual courses, others taken orally every day.
- What to watch
- Endpoints here are measured in decades, so nobody has human outcome data. Bloodwork and function markers are the only feedback you will get in a realistic timeframe.
Full guide
Spermidine: A Tracking Guide for a Polyamine Autophagy Inducer
An evidence-aware look at spermidine, a dietary polyamine linked to autophagy and longevity signals, sold as a wheat-germ-derived supplement.
Other longevity
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.