Fisetin
A plant flavonoid studied as a senolytic — a compound that clears senescent cells — typically taken in short hit-and-run pulses. Most evidence to date is preclinical.
- Half-life
- Not established
- Out of system
- —
- Route
- Oral
- Level
- Intermediate
What Fisetin is used for
- Acts as a senolytic that may help clear senescent cells
- Short pulsed dosing limits exposure while targeting aged cells
- Also has antioxidant and anti-inflammatory properties
How it's typically used
Early protocols describe roughly 1000 mg daily for two consecutive days per month, framed as reported practice and not a recommendation.
What to watch for
- Most senolytic evidence comes from animal studies, not human trials
- Oral bioavailability is low, so absorbed amounts are uncertain
- The optimal human dose and schedule remain unproven
- Sold as a dietary supplement, not evaluated by the FDA to treat any disease
About Longevity
- What they are
- Compounds studied for cellular ageing — mitochondrial function, senescent-cell clearance, telomere and autophagy pathways.
- How they're run
- Mixed routes: some injected in short annual or biannual courses, others taken orally every day.
- What to watch
- Endpoints here are measured in decades, so nobody has human outcome data. Bloodwork and function markers are the only feedback you will get in a realistic timeframe.
Full guide
Fisetin: A Tracking Guide for a Flavonoid Senolytic
An evidence-aware look at fisetin, a plant flavonoid used in intermittent senolytic protocols, and why the human data is still mostly preliminary.
Other longevity
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.