What is the half-life of SS-31 (Elamipretide)?

SS-31 (Elamipretide) has an approximate elimination half-life of 2.5 h. Short-acting — protocols usually dose daily.

How long does SS-31 (Elamipretide) stay in your system?

Roughly 97% of a dose has cleared after five half-lives — about ~13 h for SS-31 (Elamipretide). That is the window that matters for washouts, bloodwork and surgery.

How is SS-31 (Elamipretide) taken?

SS-31 (Elamipretide) is typically administered by the subcutaneous route. Trial range: ~40 mg subcutaneous daily.

What are the risks of SS-31 (Elamipretide)?

Benefit in healthy adults is unproven Still investigational Research-only outside trials

SS-31 (Elamipretide)

elamipretide bendavia mtp-131

Cardiolipin-binding tetrapeptide. Mitochondrial-disease research; clinical-trial markers.

Half-life: 2.5 h
Out of system: ~13 h
Route: Subcutaneous
Level: Advanced

Short-acting — protocols usually dose daily. After the last dose, roughly 97% has cleared in ~13 h (five half-lives) — the window that matters for washouts, bloodwork and surgery.

What SS-31 (Elamipretide) is used for

Cardiolipin-binding tetrapeptide — mitochondrial function
In clinical trials for mitochondrial disease

How it's typically used

Trial range: ~40 mg subcutaneous daily.

What to watch for

Benefit in healthy adults is unproven
Still investigational
Research-only outside trials

Common questions

What is the half-life of SS-31 (Elamipretide)?: SS-31 (Elamipretide) has an approximate elimination half-life of 2.5 h. Short-acting — protocols usually dose daily.
How long does SS-31 (Elamipretide) stay in your system?: Roughly 97% of a dose has cleared after five half-lives — about ~13 h for SS-31 (Elamipretide). That is the window that matters for washouts, bloodwork and surgery.
How is SS-31 (Elamipretide) taken?: SS-31 (Elamipretide) is typically administered by the subcutaneous route. Trial range: ~40 mg subcutaneous daily.
What are the risks of SS-31 (Elamipretide)?: Benefit in healthy adults is unproven Still investigational Research-only outside trials

About Longevity

What they are: Compounds studied for cellular ageing — mitochondrial function, senescent-cell clearance, telomere and autophagy pathways.
How they're run: Mixed routes: some injected in short annual or biannual courses, others taken orally every day.
What to watch: Endpoints here are measured in decades, so nobody has human outcome data. Bloodwork and function markers are the only feedback you will get in a realistic timeframe.

Full guide

SS-31 (Elamipretide): Tracking a Mitochondria-Targeting Tetrapeptide

A tracking guide for SS-31/elamipretide, the cardiolipin-binding peptide studied in mitochondrial disease and heart failure.

Other longevity

Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.