Raloxifene
A breast-selective SERM used to treat and prevent gynecomastia and to protect bone density. It antagonizes estrogen in breast tissue while acting as an agonist in bone.
- Half-life
- 1.2 d
- Out of system
- ~6 days
- Route
- Oral
- Level
- Intermediate
Daily dosing holds steady levels. After the last dose, roughly 97% has cleared in ~6 days (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Raloxifene is used for
- Blocks estrogen in breast tissue to treat and prevent gynecomastia
- Acts as an estrogen agonist in bone, supporting bone mineral density
- Simple oral daily dosing
How it's typically used
Literature range: 60 mg orally once daily for gynecomastia or bone protection, as reported in the research.
What to watch for
- Increases the risk of venous thromboembolism (blood clots)
- Can cause hot flashes and leg cramps
- Prescription SERM; use only under medical supervision
About Ancillaries (SERMs / AIs)
- What they are
- Support drugs — SERMs, aromatase inhibitors, and prolactin controls used to manage the side effects of androgen use or to restart natural production afterwards.
- How they're run
- Oral tablets, dosed against bloodwork rather than on a fixed schedule.
- What to watch
- These are only meaningful with labs in hand. Crushing oestrogen with an AI wrecks joints, libido, and lipids just as thoroughly as having too much of it.
Full guide
Raloxifene: A Tracking Guide for a Gynecomastia-Focused SERM
A measured, harm-reduction look at raloxifene, why it is often preferred for treating gynecomastia, and the clotting risk to watch.
Other ancillaries (serms / ais)
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.