What is the half-life of Setmelanotide?

Setmelanotide has an approximate elimination half-life of 11 h.

How long does Setmelanotide stay in your system?

Roughly 97% of a dose has cleared after five half-lives — about ~2.3 days for Setmelanotide. That is the window that matters for washouts, bloodwork and surgery.

What are the risks of Setmelanotide?

Sexual adverse reactions, including spontaneous erections Depression and suicidal ideation Skin darkening, darker moles and new moles Serious hypersensitivity reactions, including anaphylaxis

Setmelanotide

Imcivree

An 8-amino-acid cyclic peptide melanocortin 4 (MC4) receptor agonist. Approved in the US for weight in specific genetic and hypothalamic forms of obesity.

Half-life: 11 h
Out of system: ~2.3 days
Route: Subcutaneous
Level: —

Class (Melanocortin 4 (MC4) receptor agonist), half-life and route from the FDA label: Imcivree (setmelanotide) injection (U.S. National Library of Medicine, DailyMed), checked 2026-09-26.

What Setmelanotide is used for

Reduces excess body weight long term in acquired hypothalamic obesity, Bardet-Biedl syndrome, and POMC, PCSK1 or LEPR deficiency confirmed by genetic testing (FDA label)

How it's typically used

Prescription medicine in the US, for the genetic and hypothalamic conditions on its label only. The prescriber sets the dose; the FDA label is cited on this page.

What to watch for

Sexual adverse reactions, including spontaneous erections
Depression and suicidal ideation
Skin darkening, darker moles and new moles
Serious hypersensitivity reactions, including anaphylaxis

Common questions

What is the half-life of Setmelanotide?: Setmelanotide has an approximate elimination half-life of 11 h.
How long does Setmelanotide stay in your system?: Roughly 97% of a dose has cleared after five half-lives — about ~2.3 days for Setmelanotide. That is the window that matters for washouts, bloodwork and surgery.
How is Setmelanotide taken?: Setmelanotide is typically administered by the subcutaneous route. Prescription medicine in the US, for the genetic and hypothalamic conditions on its label only. The prescriber sets the dose; the FDA label is cited on this page.
What are the risks of Setmelanotide?: Sexual adverse reactions, including spontaneous erections Depression and suicidal ideation Skin darkening, darker moles and new moles Serious hypersensitivity reactions, including anaphylaxis

About Other research compounds

What they are: Nootropics, metabolic agents, and research compounds that don't fit the other classes.
How they're run: Route and schedule vary widely — check the individual entry.
What to watch: This is the least-characterised corner of the atlas. Read the full guide, and treat anything without published human data as exactly that.

Other other research compounds

Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.