What is the half-life of Leuprolide?

Leuprolide has an approximate elimination half-life of 3 h.

How long does Leuprolide stay in your system?

Roughly 97% of a dose has cleared after five half-lives — about ~15 h for Leuprolide. That is the window that matters for washouts, bloodwork and surgery.

How is Leuprolide taken?

Leuprolide is typically administered by the subcutaneous route. Prescription medicine in the US. The prescriber sets the dose and schedule; the FDA label is cited on this page.

What are the risks of Leuprolide?

Testosterone rises at first, and symptoms can briefly worsen in the first weeks (bone pain; rarely ureteral obstruction or spinal cord compression) Contraindicated with known hypersensitivity to GnRH or GnRH agonists; anaphylactic reactions have been reported

Leuprolide

Lupron leuprolide acetate

A synthetic nonapeptide GnRH agonist: it first raises LH, FSH and sex hormones, and continuous daily use then lowers them. The injection cited here is approved in the US for advanced prostate cancer.

Half-life: 3 h
Out of system: ~15 h
Route: Subcutaneous
Level: —

Class (Gonadotropin-releasing hormone (GnRH) agonist), half-life and route from the FDA label: Leuprolide Acetate Injection (U.S. National Library of Medicine, DailyMed), checked 2026-09-26.

What Leuprolide is used for

Palliative treatment of advanced prostate cancer (FDA label for leuprolide acetate injection)

How it's typically used

Prescription medicine in the US. The prescriber sets the dose and schedule; the FDA label is cited on this page.

What to watch for

Testosterone rises at first, and symptoms can briefly worsen in the first weeks (bone pain; rarely ureteral obstruction or spinal cord compression)
Contraindicated with known hypersensitivity to GnRH or GnRH agonists; anaphylactic reactions have been reported

Common questions

What is the half-life of Leuprolide?: Leuprolide has an approximate elimination half-life of 3 h.
How long does Leuprolide stay in your system?: Roughly 97% of a dose has cleared after five half-lives — about ~15 h for Leuprolide. That is the window that matters for washouts, bloodwork and surgery.
How is Leuprolide taken?: Leuprolide is typically administered by the subcutaneous route. Prescription medicine in the US. The prescriber sets the dose and schedule; the FDA label is cited on this page.
What are the risks of Leuprolide?: Testosterone rises at first, and symptoms can briefly worsen in the first weeks (bone pain; rarely ureteral obstruction or spinal cord compression) Contraindicated with known hypersensitivity to GnRH or GnRH agonists; anaphylactic reactions have been reported

About Other research compounds

What they are: Nootropics, metabolic agents, and research compounds that don't fit the other classes.
How they're run: Route and schedule vary widely — check the individual entry.
What to watch: This is the least-characterised corner of the atlas. Read the full guide, and treat anything without published human data as exactly that.

Other other research compounds

Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.