What is the half-life of Octreotide?

Octreotide has an approximate elimination half-life of 1.8 h.

How long does Octreotide stay in your system?

Roughly 97% of a dose has cleared after five half-lives — about ~9 h for Octreotide. That is the window that matters for washouts, bloodwork and surgery.

How is Octreotide taken?

Octreotide is typically administered by the subcutaneous route. Prescription medicine in the US. The prescriber sets the dose and schedule; the FDA label is cited on this page.

What are the risks of Octreotide?

Heart conduction problems, including complete atrioventricular block, have been reported Gallstones and their complications Can cause high or low blood sugar Can suppress thyroid function; new steatorrhea and falling vitamin B12 levels have been reported

Octreotide

Sandostatin

A cyclic octapeptide somatostatin analogue. Approved in the US for acromegaly and for symptoms of carcinoid tumors and VIPomas. Label elimination half-life: 1.7 to 1.9 h.

Half-life: 1.8 h
Out of system: ~9 h
Route: Subcutaneous
Level: —

Class (Somatostatin analogue), half-life and route from the FDA label: Sandostatin (octreotide acetate) injection (U.S. National Library of Medicine, DailyMed), checked 2026-09-26.

What Octreotide is used for

Acromegaly: lowers growth hormone and IGF-1 when surgery, radiation or bromocriptine are inadequate or not possible (FDA label)
Severe diarrhea and flushing from metastatic carcinoid tumors (FDA label)
Watery diarrhea from VIP-secreting tumors (FDA label)

How it's typically used

Prescription medicine in the US. The prescriber sets the dose and schedule; the FDA label is cited on this page.

What to watch for

Heart conduction problems, including complete atrioventricular block, have been reported
Gallstones and their complications
Can cause high or low blood sugar
Can suppress thyroid function; new steatorrhea and falling vitamin B12 levels have been reported

Common questions

What is the half-life of Octreotide?: Octreotide has an approximate elimination half-life of 1.8 h.
How long does Octreotide stay in your system?: Roughly 97% of a dose has cleared after five half-lives — about ~9 h for Octreotide. That is the window that matters for washouts, bloodwork and surgery.
How is Octreotide taken?: Octreotide is typically administered by the subcutaneous route. Prescription medicine in the US. The prescriber sets the dose and schedule; the FDA label is cited on this page.
What are the risks of Octreotide?: Heart conduction problems, including complete atrioventricular block, have been reported Gallstones and their complications Can cause high or low blood sugar Can suppress thyroid function; new steatorrhea and falling vitamin B12 levels have been reported

About Other research compounds

What they are: Nootropics, metabolic agents, and research compounds that don't fit the other classes.
How they're run: Route and schedule vary widely — check the individual entry.
What to watch: This is the least-characterised corner of the atlas. Read the full guide, and treat anything without published human data as exactly that.

Other other research compounds

Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.