MK-677
An orally active ghrelin-mimetic growth hormone secretagogue (ibutamoren) that raises GH and IGF-1 pulses. It is not a SARM despite often being grouped with them.
- Half-life
- 1.0 d
- Out of system
- ~5 days
- Route
- Oral
- Level
- Beginner
Daily dosing holds steady levels. After the last dose, roughly 97% has cleared in ~5 days (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What MK-677 is used for
- Sustained rises in GH and IGF-1 that can support lean mass, recovery and connective tissue
- Frequently reported to deepen sleep and noticeably increase appetite
How it's typically used
Research and trial literature reports around 25 mg once daily, usually taken at night.
What to watch for
- Commonly causes water retention, lethargy and increased appetite that not everyone wants
- Can raise fasting blood glucose and lower insulin sensitivity — monitor if pre-diabetic
- Not approved for human use; sold as an unapproved research chemical with real mislabeling risk
About Performance & GH
- What they are
- Growth-hormone secretagogues and related performance compounds. Rather than supplying GH, they push your pituitary to release more of its own in a pulse.
- How they're run
- Subcutaneous injection, most often at night on an empty stomach so the pulse lands with natural sleep-driven GH release.
- What to watch
- Water retention, tingling hands, and hunger swings are the common early signs. Raising GH raises IGF-1 — worth tracking on bloodwork, and a reason to avoid these with any cancer history.
Full guide
MK-677 (Ibutamoren): A Tracking Guide for an Oral GH Secretagogue
A measured, harm-reduction look at MK-677, what it actually does to GH and IGF-1, and the daily signals and bloodwork worth watching.
Other performance & gh
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.