A measured, harm-reduction look at MK-677, what it actually does to GH and IGF-1, and the daily signals and bloodwork worth watching.
At a glance
MK-677, also called ibutamoren, is an orally active ghrelin-mimetic growth hormone secretagogue. It is frequently mislabeled and sold alongside SARMs, but it is not a SARM - it does not bind the androgen receptor. Instead it mimics ghrelin at the GH secretagogue receptor, prompting the pituitary to release more of the body's own growth hormone, which in turn raises IGF-1.
This is an educational tracking guide, not medical advice or a recommendation. MK-677 is an unapproved research chemical, and products sold online are frequently mislabeled or underdosed.
The most consistent real-world concerns are worsened fasting glucose and insulin sensitivity, water retention, and appetite that can be hard to manage. People with any diabetes risk, high blood pressure, or a history of cancer should be especially cautious given IGF-1 elevation. Because it is unregulated, mislabeling and contamination are genuine risks, and long-term human safety data is limited. Anyone using it should track glucose and consider periodic bloodwork.
Peptid AI is an educational and self-tracking tool. Nothing in this post is medical advice. Doses mentioned reflect what is commonly reported in research literature — they are not recommendations. Always consult a qualified physician before starting, changing, or stopping any protocol.