Metformin
glucophageriometfortametglumetza
Prescription longevity drug. Tracking guide accounting for prescription status + GI side effects.
- Half-life
- 5 h
- Out of system
- ~1.0 days
- Route
- Oral
- Level
- Intermediate
Short-acting — protocols usually dose daily. After the last dose, roughly 97% has cleared in ~1.0 days (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Metformin is used for
- Prescription drug in the longevity conversation
- Improves insulin sensitivity; modest weight/anti-aging interest
How it's typically used
Typical: 500 mg daily, up to 1000 mg twice daily with food.
What to watch for
- GI side effects (diarrhea, nausea) are common
- Can deplete B12; rare lactic-acidosis risk
- Prescription-only; avoid with significant kidney impairment
About Longevity
- What they are
- Compounds studied for cellular ageing — mitochondrial function, senescent-cell clearance, telomere and autophagy pathways.
- How they're run
- Mixed routes: some injected in short annual or biannual courses, others taken orally every day.
- What to watch
- Endpoints here are measured in decades, so nobody has human outcome data. Bloodwork and function markers are the only feedback you will get in a realistic timeframe.
Full guide
Metformin: The Old Drug in the Longevity Conversation
A tracking guide for metformin that takes its prescription status and side effects seriously.
Other longevity
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.