What is the half-life of Gonadorelin (GnRH)?

Gonadorelin (GnRH) has an approximate elimination half-life of 6 min. Very short-acting — protocols dose 1–2× a day.

How long does Gonadorelin (GnRH) stay in your system?

Roughly 97% of a dose has cleared after five half-lives — about ~1 h for Gonadorelin (GnRH). That is the window that matters for washouts, bloodwork and surgery.

How is Gonadorelin (GnRH) taken?

Gonadorelin (GnRH) is typically administered by the subcutaneous route. Research range: ~100 mcg subcutaneous every other day (or pulsatile).

What are the risks of Gonadorelin (GnRH)?

Very short half-life — needs frequent/pulsatile dosing Continuous (non-pulsatile) use paradoxically suppresses Prescription-only; clinician guidance advised

Gonadorelin (GnRH)

factrel lutrepulse gnrh

GnRH agonist — HPG-axis support during TRT, fertility maintenance. Pulsatile dosing.

Half-life: 6 min
Out of system: ~1 h
Route: Subcutaneous
Level: Advanced

Very short-acting — protocols dose 1–2× a day. After the last dose, roughly 97% has cleared in ~1 h (five half-lives) — the window that matters for washouts, bloodwork and surgery.

What Gonadorelin (GnRH) is used for

Pulsatile GnRH — keeps the HPG axis active during TRT
Supports fertility and endogenous testosterone

How it's typically used

Research range: ~100 mcg subcutaneous every other day (or pulsatile).

What to watch for

Very short half-life — needs frequent/pulsatile dosing
Continuous (non-pulsatile) use paradoxically suppresses
Prescription-only; clinician guidance advised

Common questions

What is the half-life of Gonadorelin (GnRH)?: Gonadorelin (GnRH) has an approximate elimination half-life of 6 min. Very short-acting — protocols dose 1–2× a day.
How long does Gonadorelin (GnRH) stay in your system?: Roughly 97% of a dose has cleared after five half-lives — about ~1 h for Gonadorelin (GnRH). That is the window that matters for washouts, bloodwork and surgery.
How is Gonadorelin (GnRH) taken?: Gonadorelin (GnRH) is typically administered by the subcutaneous route. Research range: ~100 mcg subcutaneous every other day (or pulsatile).
What are the risks of Gonadorelin (GnRH)?: Very short half-life — needs frequent/pulsatile dosing Continuous (non-pulsatile) use paradoxically suppresses Prescription-only; clinician guidance advised

About Other research compounds

What they are: Nootropics, metabolic agents, and research compounds that don't fit the other classes.
How they're run: Route and schedule vary widely — check the individual entry.
What to watch: This is the least-characterised corner of the atlas. Read the full guide, and treat anything without published human data as exactly that.

Full guide

Gonadorelin (GnRH): A Tracking Guide for HPG Axis Support

How gonadorelin is used alongside TRT and fertility protocols, and what to actually measure.

Other other research compounds

Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.