Melanotan I (Afamelanotide)
scenesse afamelanotide mt1 mt-i melanotan 1
Slower, cleaner MT cousin — slower onset. FDA-approved for erythropoietic protoporphyria.
- Half-life
- 1 h
- Out of system
- ~5 h
- Route
- Subcutaneous
- Level
- Intermediate
Very short-acting — protocols dose 1–2× a day. After the last dose, roughly 97% has cleared in ~5 h (five half-lives) — the window that matters for washouts, bloodwork and surgery.
What Melanotan I (Afamelanotide) is used for
- Slower, cleaner Melanotan cousin — gradual tanning
- FDA-approved (as afamelanotide) for erythropoietic protoporphyria
How it's typically used
Research range: ~0.5 mg subcutaneous daily during a loading phase.
What to watch for
- Monitor moles — darkening/new lesions warrant a dermatologist
- Slower onset than Melanotan II
- Off-label tanning use is unsupervised; nausea/flushing reported
Common questions
- What is the half-life of Melanotan I (Afamelanotide)?
- Melanotan I (Afamelanotide) has an approximate elimination half-life of 1 h. Very short-acting — protocols dose 1–2× a day.
- How long does Melanotan I (Afamelanotide) stay in your system?
- Roughly 97% of a dose has cleared after five half-lives — about ~5 h for Melanotan I (Afamelanotide). That is the window that matters for washouts, bloodwork and surgery.
- How is Melanotan I (Afamelanotide) taken?
- Melanotan I (Afamelanotide) is typically administered by the subcutaneous route. Research range: ~0.5 mg subcutaneous daily during a loading phase.
- What are the risks of Melanotan I (Afamelanotide)?
- Monitor moles — darkening/new lesions warrant a dermatologist Slower onset than Melanotan II Off-label tanning use is unsupervised; nausea/flushing reported
About Skin, hair & aesthetic
- What they are
- Skin, hair, and pigmentation compounds — some injected, some formulated into topicals.
- How they're run
- Topicals go on clean skin daily; injectables run in short courses. Either way the timescale is months.
- What to watch
- Melanocortin compounds darken existing moles and can trigger nausea and flushing — get a skin check before and during. Topical peptides are cosmetic and act only where applied.
Full guide
Melanotan I (Afamelanotide): The Slower, Cleaner Cousin
How MT-1 differs from MT-II in pharmacology, side effects, and what to actually track.
Other skin, hair & aesthetic
Peptid AI is an educational and self-tracking tool — not a medical service, and not a vendor. Nothing here is medical advice, a prescription, or an endorsement. Doses reflect what is commonly reported in research literature; they are not recommendations. Many compounds listed are experimental, not approved for human use, and/or controlled substances that are illegal to possess without a prescription in many countries. Always consult a qualified physician before starting, changing, or stopping any protocol.