HCG: A Tracking Guide for TRT and Fertility Contexts

Human chorionic gonadotropin (HCG) is a glycoprotein hormone produced by the placenta during pregnancy. Structurally it shares the alpha subunit with LH, FSH, and TSH; its beta subunit is similar enough to LH that it binds LH receptors in the testis and ovary. That is the basis for almost every off-label use.

This guide covers the realistic tracking picture for men using HCG alongside TRT or for fertility, not the long-debunked HCG diet.

What it does

• Binds LH receptors on Leydig cells
• Stimulates intratesticular testosterone production
• Preserves testicular volume during exogenous testosterone use
• Supports spermatogenesis when used with FSH or alone over months
• Half-life is much longer than LH (around 24-36 hours)

Typical protocol shape

Commonly reported protocols among TRT self-experimenters:

• Testicular maintenance: 250-500 IU subcutaneous, 2-3x per week
• Fertility-focused: 1000-3000 IU 2-3x per week, sometimes with added FSH
• Post-cycle or HPTA restart: variable, often combined with SERMs

Higher doses do not always mean better outcomes; estradiol conversion in the testis becomes a problem.

What to track daily

• Dose, time, site
• AM erection quality (0-10)
• Libido (0-10)
• Mood: irritability, anxiety
• Acne or oily skin changes
• Injection-site reaction

What to track weekly

• Testicular volume (orchidometer or measured)
• Sleep averages
• Bodyweight and waist
• Subjective "well-being" score

A simple Peptid AI custom field for testicular volume gives you a number you can actually plot.

Bloodwork worth doing

• Baseline: total and free T, estradiol (sensitive), SHBG, prolactin, hematocrit
• 6 weeks in: same panel
• Some protocols cause sharp estradiol rises even at modest doses; trend the line
• Semen analysis at baseline and 3 months if fertility is the goal

Realistic expectations

• Testicular volume usually returns within 4-8 weeks of starting
• Mood and libido changes are highly individual
• Spermatogenesis recovery on HCG alone takes 3-6 months when it works
• The "HCG diet" has been repeatedly shown to do nothing for fat loss beyond the starvation it accompanies

Common mistakes

• Stacking HCG into an already-elevated estradiol situation
• Treating it as interchangeable with gonadorelin
• Running fertility doses indefinitely (Leydig cell desensitization is a real concern at sustained high doses)
• Skipping baseline semen analysis when fertility is the actual goal

A tracking template

• Daily: dose, time, libido, AM erection, mood, skin
• Weekly: testicular volume, weight, sleep
• 6-weekly: hormone panel with sensitive E2
• Quarterly: semen analysis if relevant

Safety notes

Common reported issues: estradiol elevation, acne, mood swings, gynecomastia at higher doses. Headache and injection-site reactions occur. Anyone with a history of hormone-sensitive cancers should not be self-experimenting.

Peptid AI is an educational and self-tracking tool. Nothing in this post is medical advice. Doses mentioned reflect what is commonly reported in research literature — they are not recommendations. Always consult a qualified physician before starting, changing, or stopping any protocol.